Actin filament network formation

Across TCGA patient cohorts, RNA activity of the Actin filament network formation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CARMIL1, KRT19, and CARMIL1_S1094, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Actin filament network formation activity versus CARMIL1 in LSCC (Pearson r = 0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CARMIL1 →	+0.374	+0.067	<.001	.002	3	7
LSCC	KRT19 →	+0.580	+0.077	.004	<.001	3	6
LSCC	CARMIL1_S1094 →	+0.677	+0.110	<.001	.002	3	6
HNSC	ARHGAP45 →	-0.415	-0.081	<.001	.004	3	6
LUAD	PTPRC_S975 →	-0.341	-0.065	<.001	<.001	3	6
HNSC	DOCK2 →	-0.457	-0.091	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051639 vs CARMIL1 — LSCC

Explore this scatter interactively →