Actin filament network formation

Across TCGA cell cohorts, RNA activity of the Actin filament network formation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TATDN2, MTMR14, and TRANK1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TATDN2 grouped by Actin filament network formation-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TATDN2 →	-0.828	-1.102	.004	.009	2	4
URINARY_TRACT	MTMR14 →	-0.726	-1.102	.002	.009	3	3
URINARY_TRACT	TRANK1 →	-2.863	-1.893	<.001	<.001	3	3
URINARY_TRACT	MAST3 →	-1.047	-1.504	.007	.007	3	3
KIDNEY	FLNC →	-2.829	-0.653	.006	.004	3	3
CNS	TMEM245 →	-0.474	-0.849	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TATDN2 by Actin filament network formation activity — URINARY_TRACT

Explore this box plot interactively →