Actin filament network formation

Across TCGA cell cohorts, RNA activity of the Actin filament network formation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LPXN, COTL1, and ARPC2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Actin filament network formation activity versus LPXN in BLOOD_Myeloma (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	LPXN →	+3.975	+2.112	<.001	.001	3	6
BREAST	COTL1 →	+2.200	+1.168	.001	<.001	3	6
BLOOD_Leukemia	ARPC2 →	+0.892	+0.283	<.001	<.001	3	6
BREAST	CORO1C →	+0.889	+1.161	.004	<.001	3	5
BONE	ACTN1 →	+1.783	+1.319	.001	.002	3	5
BREAST	FOSL1 →	+2.873	+1.114	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051639 vs LPXN — BLOOD_Myeloma

Explore this scatter interactively →