Norepinephrine uptake

Across TCGA patient cohorts, RNA activity of the Norepinephrine uptake pathway is significantly associated with the RNA expression of multiple genes, with the TGCT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1S, CDH11, and DCN, each associated with the pathway in up to 23 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Norepinephrine uptake activity versus C1S in TGCT (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	C1S →	-1.507	-0.055	<.001	<.001	3	23
ACC	CDH11 →	-2.010	-0.093	<.001	<.001	3	21
SARC	DCN →	-2.774	-0.086	<.001	<.001	3	20
THYM	GLIPR1 →	-0.712	-0.072	<.001	.001	1	22
TGCT	C1R →	-1.529	-0.053	<.001	<.001	3	20
THYM	PRRX1 →	-1.885	-0.073	<.001	.002	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051620 vs C1S — TGCT

Explore this scatter interactively →