Norepinephrine uptake

Across TCGA patient cohorts, RNA activity of the Norepinephrine uptake pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CEP170, NRP2, and CES1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Norepinephrine uptake activity versus CEP170 in BRCA (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CEP170 →	-0.411	-0.117	<.001	<.001	3	6
BRCA	NRP2 →	-0.382	-0.084	.002	.002	3	6
OV	CES1 →	-0.842	-0.102	<.001	.001	3	5
CCRCC	CNDP2 →	+0.469	+0.118	<.001	<.001	3	5
OV	CRTAP →	-0.666	-0.118	<.001	<.001	3	5
LUAD	MAP1B_S614 →	-1.079	-0.118	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051620 vs CEP170 — BRCA

Explore this scatter interactively →