Norepinephrine uptake

pathway activity — cross-omics
GO:0051620Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Norepinephrine uptake pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR193A, RN7SL76P, and HBA1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECMIR193A →-1.501-0.158.002<.00134
GBMRN7SL76P →-0.571-0.118.002.00533
OVHBA1 →+1.866+0.117.003.00233
UCECUSP9Y →+0.100+0.145.006.00233
UCECIFIT2 →-1.176-0.116<.001.00533
UCECZDHHC4 →-0.758-0.190.009.00233
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration