Norepinephrine uptake

Across TCGA cell cohorts, RNA activity of the Norepinephrine uptake pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACTB, SNCA, and HGD, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACTB grouped by Norepinephrine uptake-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ACTB →	-0.435	-0.990	<.001	<.001	3	12
LARGE_INTESTINE	SNCA →	-0.606	-1.748	.001	<.001	3	7
CNS	HGD →	-0.236	-0.834	<.001	.004	3	4
CNS	PGBD1 →	-0.298	-1.074	<.001	.001	3	4
CNS	ABL2 →	-0.202	-0.927	.003	<.001	3	4
OESOPHAGUS	PITX3 →	-0.122	-0.243	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACTB by Norepinephrine uptake activity — BREAST

Explore this box plot interactively →