Serotonin uptake

Across TCGA patient cohorts, RNA activity of the Serotonin uptake pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLG, MED8, and ATRN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Serotonin uptake activity versus PLG in BRCA (Pearson r = 0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PLG →	+0.544	+0.055	<.001	<.001	3	4
UCEC	MED8 →	-0.150	-0.070	.006	.001	3	4
BRCA	ATRN →	+0.525	+0.063	<.001	<.001	3	4
BRCA	PAM →	+0.403	+0.043	.003	.005	3	4
BRCA	APCS →	+0.775	+0.040	.001	<.001	3	4
COAD	TOM1L2_S160 →	+0.528	+0.051	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051610 vs PLG — BRCA

Explore this scatter interactively →