Serotonin uptake

Across TCGA cell cohorts, RNA activity of the Serotonin uptake pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NELL2, FAM131C, and FAM89A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NELL2 grouped by Serotonin uptake-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NELL2 →	+1.906	+1.251	.001	.001	3	4
KIDNEY	FAM131C →	+1.312	+1.316	.002	<.001	3	4
BREAST	FAM89A →	-1.516	-1.026	<.001	.001	3	3
BREAST	H2AC8 →	+1.209	+1.030	.003	<.001	3	3
BREAST	GNG14 →	+0.373	+0.956	.001	.002	3	3
BONE	FBXW4 →	-0.954	-0.770	.005	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NELL2 by Serotonin uptake activity — LARGE_INTESTINE

Explore this box plot interactively →