Histamine transport

Across TCGA patient cohorts, RNA activity of the Histamine transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SASH3, RFC2, and ADA2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Histamine transport activity versus SASH3 in GBM (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SASH3 →	+0.416	+0.064	<.001	<.001	3	6
LSCC	RFC2 →	-0.355	-0.060	<.001	<.001	3	6
LSCC	ADA2 →	+0.441	+0.066	<.001	<.001	3	6
LSCC	CORO1A →	+0.553	+0.078	<.001	<.001	3	6
LSCC	CTSL →	+0.299	+0.054	<.001	<.001	3	6
LSCC	FKBP15 →	+0.242	+0.069	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051608 vs SASH3 — GBM

Explore this scatter interactively →