Histamine transport

Across TCGA patient cohorts, RNA activity of the Histamine transport pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCRL2, SASH3, and GBP5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Histamine transport activity versus CCRL2 in UCEC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCRL2 →	+0.735	+0.326	<.001	.001	3	6
CCRCC	SASH3 →	+0.553	+0.204	.003	.005	3	6
UCEC	GBP5 →	+1.155	+0.227	<.001	.006	3	6
CCRCC	SNX20 →	+0.541	+0.223	.006	.002	3	6
UCEC	PTAFR →	+0.963	+0.279	<.001	<.001	3	6
CCRCC	C1QA →	+0.470	+0.261	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051608 vs CCRL2 — UCEC

Explore this scatter interactively →