Histamine transport

Across TCGA patient cohorts, RNA activity of the Histamine transport pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CYBB, EVI2B_S268, and HCK, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Histamine transport activity versus CYBB in PDAC (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CYBB →	+0.758	+0.704	<.001	<.001	3	6
LSCC	EVI2B_S268 →	+1.195	+0.319	<.001	.001	3	6
UCEC	HCK →	+0.459	+0.262	<.001	<.001	2	7
BRCA	ITGB2 →	+0.660	+0.225	<.001	.002	3	6
BRCA	LYN →	+0.446	+0.194	<.001	<.001	3	6
COAD	LYN_S13 →	+0.808	+0.341	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051608 vs CYBB — PDAC

Explore this scatter interactively →