Histamine transport

Across TCGA cell cohorts, RNA activity of the Histamine transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLA2G6, SNAP23, and P2RX5, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Histamine transport activity versus PLA2G6 in BLOOD_Leukemia (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PLA2G6 →	+1.903	+0.850	<.001	.003	3	3
LARGE_INTESTINE	SNAP23 →	+1.193	+1.862	.008	<.001	3	2
BLOOD_Leukemia	P2RX5 →	+1.662	+0.898	.007	.003	3	2
BLOOD_Leukemia	PPP1R13B →	+1.471	+0.792	<.001	<.001	3	2
BLOOD_Leukemia	TCF4 →	+2.097	+0.962	.001	.001	3	2
BLOOD_Lymphoma	MT2A →	-3.100	-1.005	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051608 vs PLA2G6 — BLOOD_Leukemia

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