Response to electrical stimulus

Across TCGA patient cohorts, RNA activity of the Response to electrical stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RRS1, SUGP1_S485, and SRRM2_S1424, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to electrical stimulus activity versus RRS1 in BRCA (Pearson r = -0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RRS1 →	-0.552	-0.044	<.001	<.001	3	5
BRCA	SUGP1_S485 →	-0.348	-0.024	.002	.009	3	5
CCRCC	SRRM2_S1424 →	-0.505	-0.049	.007	.001	3	5
BRCA	CNRIP1 →	+0.602	+0.045	<.001	<.001	3	5
CCRCC	PPP3CC_S483 →	-0.386	-0.036	<.001	<.001	3	5
BRCA	CD248 →	+0.489	+0.042	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051602 vs RRS1 — BRCA

Explore this scatter interactively →