Response to electrical stimulus

Across TCGA patient cohorts, RNA activity of the Response to electrical stimulus pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C7, PDE1A, and ABCA8, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to electrical stimulus activity versus C7 in BRCA (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	C7 →	+1.763	+0.718	<.001	.002	3	9
BRCA	PDE1A →	+1.200	+0.983	<.001	<.001	3	8
HNSC	ABCA8 →	+1.124	+0.763	<.001	<.001	3	8
BRCA	ADH1B →	+2.065	+0.780	<.001	<.001	3	8
BRCA	PODN →	+1.153	+0.731	<.001	<.001	3	8
UCEC	LMOD1 →	+1.229	+0.777	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051602 vs C7 — BRCA

Explore this scatter interactively →