Exocyst localization

Across TCGA patient cohorts, RNA activity of the Exocyst localization pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TARS1, DNAJC21_S370, and PTPRC, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Exocyst localization activity versus TARS1 in LSCC (Pearson r = 0.58).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TARS1 →	+0.451	+0.087	<.001	<.001	3	5
LUAD	DNAJC21_S370 →	+0.409	+0.066	<.001	<.001	3	5
HNSC	PTPRC →	-0.337	-0.092	.002	.009	3	5
LSCC	OTULIN →	+0.259	+0.075	<.001	<.001	3	5
LUAD	PDCD6 →	+0.325	+0.088	<.001	<.001	3	5
LSCC	RCSD1_S351 →	-0.548	-0.079	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051601 vs TARS1 — LSCC

Explore this scatter interactively →