Exocyst localization

Across TCGA cell cohorts, RNA activity of the Exocyst localization pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFAIP2, EXOC3, and ZNF622, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Exocyst localization activity versus TNFAIP2 in BONE (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TNFAIP2 →	+4.314	+0.271	<.001	<.001	3	13
OESOPHAGUS	EXOC3 →	+1.134	+0.356	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	ZNF622 →	+0.842	+0.165	<.001	.007	3	10
BONE	CATSPER1 →	+1.686	+0.324	<.001	<.001	3	10
BONE	TRIO →	+1.712	+0.363	<.001	<.001	3	10
LIVER	MED10 →	+0.971	+0.202	.003	.008	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051601 vs TNFAIP2 — BONE

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