Response to hydrostatic pressure

Across TCGA patient cohorts, RNA activity of the Response to hydrostatic pressure pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLEC, RRAS, and NUP133, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to hydrostatic pressure activity versus PLEC in PDAC (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PLEC →	+0.811	+0.411	<.001	<.001	3	6
PDAC	RRAS →	+0.584	+0.311	<.001	.001	3	6
GBM	NUP133 →	-0.252	-0.560	.002	.005	3	5
BRCA	ITGA3 →	+1.417	+0.434	<.001	<.001	3	5
PDAC	LGALS1 →	+0.597	+0.296	.001	<.001	3	4
LUAD	LAMB3 →	+1.344	+0.226	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051599 vs PLEC — PDAC

Explore this scatter interactively →