Response to hydrostatic pressure

Across TCGA cell cohorts, RNA activity of the Response to hydrostatic pressure pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUB, APBB1, and PRXL2B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TUB grouped by Response to hydrostatic pressure-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TUB →	-1.581	-0.864	<.001	<.001	3	4
PANCREAS	APBB1 →	-1.998	-0.923	.006	.003	3	4
BLOOD_Lymphoma	PRXL2B →	+1.745	+1.539	<.001	<.001	3	4
CNS	OMA1 →	+0.627	+0.983	.004	.006	3	4
LARGE_INTESTINE	LNP1 →	-1.160	-1.160	.001	.006	3	4
SOFT_TISSUE	ASAH1 →	+1.168	+0.848	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TUB by Response to hydrostatic pressure activity — PANCREAS

Explore this box plot interactively →