Response to calcium ion

Across TCGA patient cohorts, RNA activity of the Response to calcium ion pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RRP9, CHERP, and SCAF1_S614, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to calcium ion activity versus RRP9 in GBM (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RRP9 →	-0.411	-0.061	<.001	<.001	3	6
GBM	CHERP →	-0.299	-0.059	<.001	<.001	3	6
LSCC	SCAF1_S614 →	-1.239	-0.034	<.001	<.001	3	6
CCRCC	USP36 →	-0.376	-0.028	.008	.004	3	6
LSCC	POLR1E →	-0.314	-0.027	<.001	<.001	3	6
GBM	RSBN1 →	-0.184	-0.032	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051592 vs RRP9 — GBM

Explore this scatter interactively →