Response to calcium ion

Across TCGA cell cohorts, RNA activity of the Response to calcium ion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OASL, CTDSP1, and GLB1L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OASL grouped by Response to calcium ion-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OASL →	-0.632	-0.698	<.001	.001	3	4
KIDNEY	CTDSP1 →	+0.695	+0.910	.002	.006	3	3
PANCREAS	GLB1L →	+0.831	+1.176	.003	<.001	3	3
KIDNEY	KLHDC7A →	+1.920	+0.948	.005	.007	3	3
KIDNEY	TMEM131 →	+0.838	+1.189	.005	.001	3	3
BREAST	GBP2 →	-2.400	-1.110	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OASL by Response to calcium ion activity — BLOOD_Leukemia

Explore this box plot interactively →