Response to calcium ion

Across TCGA cell cohorts, RNA activity of the Response to calcium ion pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JAK1, GBP3, and ADAM9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to calcium ion activity versus JAK1 in OVARY (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	JAK1 →	+1.617	+0.256	.004	.009	3	6
LUNG_NSCLC_LUSC	GBP3 →	+4.122	+0.136	<.001	.006	3	5
CNS	ADAM9 →	+1.142	+0.252	.001	<.001	3	5
OESOPHAGUS	STX12 →	+0.765	+0.200	.006	<.001	2	6
BLOOD_Leukemia	RBMS1 →	+1.176	+0.190	.004	<.001	3	5
LUNG_NSCLC_LUSC	SH3BGRL3 →	+2.752	+0.135	.002	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051592 vs JAK1 — OVARY

Explore this scatter interactively →