Response to cAMP

Across TCGA patient cohorts, RNA activity of the Response to cAMP pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RRP9, FANCE, and MCM4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to cAMP activity versus RRP9 in OV (Pearson r = -0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RRP9 →	-0.532	-0.155	<.001	<.001	3	5
UCEC	FANCE →	-0.761	-0.216	<.001	.003	3	5
UCEC	MCM4 →	-0.611	-0.155	<.001	.009	3	5
UCEC	MCM3 →	-0.641	-0.188	<.001	.001	3	5
GBM	KIF20A →	-0.996	-0.174	<.001	<.001	3	5
BRCA	PRIM1 →	-0.464	-0.169	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051591 vs RRP9 — OV

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