Response to cAMP

Across TCGA cell cohorts, RNA activity of the Response to cAMP pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACTB, GORASP2, and PPP1CC, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACTB grouped by Response to cAMP-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ACTB →	+1.080	+0.240	.002	.001	3	4
BONE	GORASP2 →	+0.428	+1.167	.002	.003	3	3
OESOPHAGUS	PPP1CC →	-0.485	-0.188	.009	.001	3	3
STOMACH	FSBP →	-1.492	-0.267	<.001	<.001	3	3
LIVER	PRMT2 →	+1.085	+0.284	.002	.004	3	3
LIVER	PSMD13 →	+0.888	+0.275	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACTB by Response to cAMP activity — LIVER

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