Response to cAMP

Across TCGA cell cohorts, RNA activity of the Response to cAMP pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DUSP1, FOSB, and ZFP36, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to cAMP activity versus DUSP1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DUSP1 →	+2.528	+0.126	<.001	<.001	3	15
LIVER	FOSB →	+3.861	+0.070	.001	.003	3	15
UPPER_AERODIGESTIVE_TRACT	ZFP36 →	+1.908	+0.099	<.001	.001	3	13
KIDNEY	FOS →	+3.507	+0.071	<.001	<.001	3	13
LIVER	JUNB →	+2.356	+0.067	.001	.001	3	11
STOMACH	EGR1 →	+1.827	+0.062	.001	.002	2	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051591 vs DUSP1 — UPPER_AERODIGESTIVE_TRACT

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