Response to cAMP

Across TCGA cell cohorts, RNA activity of the Response to cAMP pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOXP1, MGRN1, and UGDH, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to cAMP activity versus FOXP1 in BONE (Pearson r = -0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	FOXP1 →	-1.146	-0.367	.003	.002	3	5
URINARY_TRACT	MGRN1 →	-0.788	-0.263	.001	.001	3	5
BREAST	UGDH →	-1.686	-0.243	.008	.001	2	6
BLOOD_Lymphoma	ITGA3 →	-2.348	-0.182	.001	.006	3	4
BLOOD_Myeloma	PLEKHA2 →	-2.033	-0.331	.008	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	KIAA0895 →	+1.229	+0.239	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051591 vs FOXP1 — BONE

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