Positive regulation of neurotransmitter transport

Across TCGA patient cohorts, RNA activity of the Positive regulation of neurotransmitter transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STXBP1, SYN1_S568, and NPY_S82, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of neurotransmitter transport activity versus STXBP1 in GBM (Pearson r = 0.81).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	STXBP1 →	+1.002	+1.141	<.001	<.001	3	4
GBM	SYN1_S568 →	+1.674	+1.462	<.001	<.001	3	3
BRCA	NPY_S82 →	+1.477	+1.457	<.001	<.001	3	3
GBM	CACNA2D2 →	+0.704	+0.874	<.001	<.001	3	3
OV	IQCE_S130 →	+1.331	+1.059	<.001	<.001	3	3
BRCA	SLC4A4_S1026 →	+1.309	+0.825	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051590 vs STXBP1 — GBM

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