Positive regulation of neurotransmitter transport

Across TCGA cell cohorts, RNA activity of the Positive regulation of neurotransmitter transport pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDR2, NPTXR, and CEP162, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDR2 grouped by Positive regulation of neurotransmitter transport-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CDR2 →	+0.461	+0.902	<.001	.001	3	5
STOMACH	NPTXR →	+2.028	+1.212	<.001	.002	3	4
LUNG_SCLC	CEP162 →	+1.124	+1.295	.002	<.001	3	4
LUNG_SCLC	HINT2 →	+1.036	+1.254	.004	.002	3	4
LUNG_SCLC	TP53BP2 →	+0.778	+1.109	.002	.005	3	4
STOMACH	KPNA5 →	+1.303	+1.306	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDR2 by Positive regulation of neurotransmitter transport activity — SKIN

Explore this box plot interactively →