Negative regulation of neurotransmitter transport

Across TCGA patient cohorts, RNA activity of the Negative regulation of neurotransmitter transport pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRBV29-1, C17orf75, and CD48, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of neurotransmitter transport activity versus TRBV29-1 in LUAD (Pearson r = -0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TRBV29-1 →	-0.402	-0.484	.004	.001	3	4
GBM	C17orf75 →	+0.383	+0.314	<.001	<.001	3	4
LUAD	CD48 →	-0.449	-0.640	.009	.003	2	4
LUAD	SIT1 →	-0.367	-0.514	.005	<.001	3	3
LUAD	ITGB7 →	-0.419	-0.688	.009	.001	3	3
LUAD	GPR174 →	-0.391	-0.560	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051589 vs TRBV29-1 — LUAD

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