Negative regulation of neurotransmitter transport

Across TCGA cell cohorts, RNA activity of the Negative regulation of neurotransmitter transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAF6L, AGAP9, and BCAT1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TAF6L grouped by Negative regulation of neurotransmitter transport-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TAF6L →	+0.884	+1.276	.005	.003	3	5
BLOOD_Myeloma	AGAP9 →	+1.736	+1.895	.005	<.001	3	5
PANCREAS	BCAT1 →	+3.269	+1.265	<.001	.001	3	4
LUNG_NSCLC_LUAD	ACSL4 →	+0.865	+0.657	.008	.006	2	5
SKIN	BOLA2B →	-0.640	-1.041	.009	.002	3	4
LUNG_NSCLC_LUSC	CHCHD6 →	+0.695	+0.918	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TAF6L by Negative regulation of neurotransmitter transport activity — LUNG_SCLC

Explore this box plot interactively →