Negative regulation of neurotransmitter transport

Across TCGA cell cohorts, RNA activity of the Negative regulation of neurotransmitter transport pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM185A, PIAS3, and BLOC1S6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of neurotransmitter transport activity versus FAM185A in SOFT_TISSUE (Pearson r = 0.91).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	FAM185A →	+0.891	+0.304	.002	.002	3	4
STOMACH	PIAS3 →	-1.372	-0.531	.009	.003	3	3
LARGE_INTESTINE	BLOC1S6 →	+0.624	+0.345	.004	.006	3	3
CNS	ZCCHC7 →	-0.569	-0.391	.007	<.001	3	3
BLOOD_Leukemia	ALKBH2 →	+0.740	+1.344	.001	.006	3	3
SOFT_TISSUE	SLC51A →	+0.640	+0.311	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051589 vs FAM185A — SOFT_TISSUE

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