Regulation of neurotransmitter transport

Across TCGA patient cohorts, RNA activity of the Regulation of neurotransmitter transport pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEM1, VRK1, and DDX55, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neurotransmitter transport activity versus SEM1 in LSCC (Pearson r = -0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SEM1 →	-0.324	-0.660	.003	<.001	3	5
LSCC	VRK1 →	-0.533	-0.479	.002	.009	3	4
LSCC	DDX55 →	-0.479	-0.591	<.001	.001	3	4
UCEC	NUP107 →	-0.447	-0.524	.002	<.001	3	4
UCEC	SLIRP →	-0.557	-0.357	<.001	.001	3	4
UCEC	RAN →	-0.600	-0.402	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051588 vs SEM1 — LSCC

Explore this scatter interactively →