Regulation of neurotransmitter transport

Across TCGA cell cohorts, RNA activity of the Regulation of neurotransmitter transport pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC102A, GABBR1, and ZNF594, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neurotransmitter transport activity versus CCDC102A in BREAST (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CCDC102A →	-1.154	-0.098	<.001	<.001	3	12
LUNG_NSCLC_LUSC	GABBR1 →	-1.877	-0.093	.003	.001	3	11
UPPER_AERODIGESTIVE_TRACT	ZNF594 →	-0.975	-0.102	.005	<.001	3	11
OESOPHAGUS	ANKRD63 →	-0.381	-0.145	.002	.001	3	11
LIVER	ZDBF2 →	-1.476	-0.104	.001	.001	3	11
PANCREAS	TGM1 →	-0.996	-0.079	.008	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051588 vs CCDC102A — BREAST

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