Regulation of neurotransmitter transport

Across TCGA cell cohorts, RNA activity of the Regulation of neurotransmitter transport pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKT3, RAB11FIP4, and PDLIM7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neurotransmitter transport activity versus AKT3 in LIVER (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	AKT3 →	+3.257	+1.395	.006	.003	3	5
CNS	RAB11FIP4 →	-1.571	-1.056	.001	<.001	3	5
BLOOD_Leukemia	PDLIM7 →	+0.998	+0.764	<.001	.004	3	5
BREAST	RSAD1 →	-1.167	-0.945	<.001	<.001	3	5
PANCREAS	FST →	+3.460	+0.142	.006	.005	3	5
BLOOD_Leukemia	HSPG2 →	+2.647	+1.103	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051588 vs AKT3 — LIVER

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