Positive regulation of neurotransmitter uptake

Across TCGA patient cohorts, RNA activity of the Positive regulation of neurotransmitter uptake pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRIP10, CES3, and PARP4_T101, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of neurotransmitter uptake activity versus TRIP10 in GBM (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TRIP10 →	+0.341	+0.059	<.001	<.001	3	5
OV	CES3 →	+0.904	+0.175	<.001	<.001	3	5
GBM	PARP4_T101 →	+0.426	+0.065	.001	.001	3	5
HNSC	PGAM1_S31 →	+0.518	+0.105	<.001	<.001	3	5
GBM	PTPN1 →	+0.217	+0.069	<.001	.001	3	5
HNSC	USP15_S229 →	+0.491	+0.151	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051582 vs TRIP10 — GBM

Explore this scatter interactively →