Positive regulation of neurotransmitter uptake

Across TCGA cell cohorts, RNA activity of the Positive regulation of neurotransmitter uptake pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAMSAP1, RELL2, and TYRO3, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of neurotransmitter uptake activity versus CAMSAP1 in LUNG_SCLC (Pearson r = -0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CAMSAP1 →	-0.789	-0.326	.004	.003	3	2
LUNG_SCLC	RELL2 →	+1.250	+0.396	.007	.002	3	2
LUNG_NSCLC_LUAD	TYRO3 →	+1.644	+0.194	<.001	.005	3	1
PANCREAS	TIMM50 →	-0.551	-0.221	.003	.009	2	2
LUNG_NSCLC_LUAD	CDKN3 →	+0.899	+0.178	.008	.009	3	1
LUNG_NSCLC_LUAD	CD48 →	+0.319	+0.194	.009	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051582 vs CAMSAP1 — LUNG_SCLC

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