Positive regulation of neurotransmitter uptake

Across TCGA cell cohorts, RNA activity of the Positive regulation of neurotransmitter uptake pathway is significantly associated with the drug response of multiple features, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are PLX-4720, Vismodegib, and Refametinib, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLX-4720 grouped by Positive regulation of neurotransmitter uptake-low versus -high activity in PANCREAS.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PLX-4720 →	-1.045	-0.239	.037	.025	3	5
LUNG_NSCLC_LUAD	Vismodegib →	-0.580	-0.153	.016	.010	3	4
CNS	Refametinib →	-1.224	-0.244	.010	.030	3	4
LUNG_NSCLC_LUAD	Motesanib →	-0.486	-0.153	.039	.010	3	3
LUNG_NSCLC_LUAD	CCT245232 →	-0.680	-0.153	.030	.010	3	3
LUNG_NSCLC_LUAD	Venetoclax →	-0.506	-0.153	.038	.010	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLX-4720 by Positive regulation of neurotransmitter uptake activity — PANCREAS

Explore this box plot interactively →