Regulation of neurotransmitter uptake

Across TCGA cell cohorts, RNA activity of the Regulation of neurotransmitter uptake pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FLOT1, ANP32E, and NCAPD3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neurotransmitter uptake activity versus FLOT1 in BLOOD_Lymphoma (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	FLOT1 →	+2.094	+0.812	<.001	.005	3	7
SOFT_TISSUE	ANP32E →	-1.045	-0.204	.006	.003	3	5
SOFT_TISSUE	NCAPD3 →	-1.326	-0.281	.005	.004	3	5
SOFT_TISSUE	PTPRH →	+1.936	+0.222	<.001	.006	3	5
LIVER	NIBAN1 →	+3.591	+0.184	<.001	.008	3	5
PANCREAS	PRPF4 →	-1.091	-0.316	.005	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051580 vs FLOT1 — BLOOD_Lymphoma

Explore this scatter interactively →