Positive regulation of mitochondrial calcium ion concentration

Across TCGA patient cohorts, RNA activity of the Positive regulation of mitochondrial calcium ion concentration pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF419, RPS3A, and DHX35, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mitochondrial calcium ion concentration activity versus ZNF419 in BRCA (Pearson r = -0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZNF419 →	-0.357	-0.154	.001	.001	3	5
CCRCC	RPS3A →	-0.362	-0.162	.002	.005	3	5
LSCC	DHX35 →	-0.569	-0.244	<.001	<.001	3	4
LSCC	FGF12 →	-0.901	-0.241	.002	.001	3	4
LSCC	ZFP37 →	-0.384	-0.195	.006	.001	3	4
LSCC	SCAF8 →	-0.394	-0.222	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051561 vs ZNF419 — BRCA

Explore this scatter interactively →