Positive regulation of mitochondrial calcium ion concentration

Across TCGA cell cohorts, RNA activity of the Positive regulation of mitochondrial calcium ion concentration pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM20C, FEM1A, and NKD2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAM20C grouped by Positive regulation of mitochondrial calcium ion concentration-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	FAM20C →	+2.061	+0.723	.001	.004	3	5
OESOPHAGUS	FEM1A →	-0.571	-1.159	<.001	.002	3	5
BLOOD_Leukemia	NKD2 →	+2.667	+1.063	<.001	.005	3	4
LUNG_SCLC	HNRNPAB →	+0.660	+1.341	.004	.001	3	4
CNS	MED10 →	-0.441	-0.806	.004	.002	3	4
SOFT_TISSUE	FAM160B2 →	-0.934	-1.259	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAM20C by Positive regulation of mitochondrial calcium ion concentration activity — LUNG_NSCLC_LUAD

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