Positive regulation of mitochondrial calcium ion concentration

Across TCGA cell cohorts, RNA activity of the Positive regulation of mitochondrial calcium ion concentration pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TGM2, MAST4, and LARGE1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mitochondrial calcium ion concentration activity versus TGM2 in LUNG_NSCLC_LUAD (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TGM2 →	+3.059	+1.149	<.001	<.001	3	7
OVARY	MAST4 →	+0.693	+1.020	.008	<.001	3	7
BREAST	LARGE1 →	-2.080	-1.257	<.001	<.001	3	6
LIVER	IGFBP6 →	+3.731	+1.402	.001	.007	3	6
OESOPHAGUS	CDA →	+4.088	+1.388	<.001	.002	3	6
SKIN	S100A11 →	+1.264	+1.208	.004	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051561 vs TGM2 — LUNG_NSCLC_LUAD

Explore this scatter interactively →