Mitochondrial calcium ion homeostasis

Across TCGA patient cohorts, RNA activity of the Mitochondrial calcium ion homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NES, RPS8_T130, and FERMT2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial calcium ion homeostasis activity versus NES in BRCA (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NES →	+0.293	+0.023	.009	.004	3	6
COAD	RPS8_T130 →	-0.245	-0.025	.003	.001	3	6
PDAC	FERMT2 →	+0.390	+0.048	<.001	<.001	3	6
CCRCC	CSRP1 →	+0.663	+0.038	<.001	<.001	3	6
OV	TLN1 →	+0.265	+0.040	.002	.004	3	5
OV	PCYT1A_S323 →	-1.481	-0.052	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051560 vs NES — BRCA

Explore this scatter interactively →