Mitochondrial calcium ion homeostasis

Across TCGA patient cohorts, RNA activity of the Mitochondrial calcium ion homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIPIN, SPARCL1, and MAPK11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial calcium ion homeostasis activity versus TIPIN in UCEC (Pearson r = -0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIPIN →	-0.425	-0.141	.003	.009	3	5
PDAC	SPARCL1 →	-0.501	-0.143	<.001	<.001	3	5
GBM	MAPK11 →	-0.631	-0.168	<.001	<.001	3	5
GBM	BLM →	-0.803	-0.160	<.001	<.001	3	5
LUAD	TCF12 →	-0.296	-0.156	<.001	.001	3	5
OV	CLIC2 →	-0.671	-0.168	.003	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051560 vs TIPIN — UCEC

Explore this scatter interactively →