Flavone metabolic process

Across TCGA patient cohorts, RNA activity of the Flavone metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR36, TARDBPP1, and RPS3AP35, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Flavone metabolic process activity versus WDR36 in CCRCC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	WDR36 →	-0.559	-1.645	.001	<.001	3	2
CCRCC	TARDBPP1 →	+0.245	+1.644	.009	<.001	3	2
CCRCC	RPS3AP35 →	+0.160	+1.565	.003	<.001	3	2
PDAC	BCL7C →	-0.431	-0.261	<.001	<.001	3	2
PDAC	MBNL2 →	-0.483	-0.191	<.001	.006	3	2
PDAC	GDF3 →	-0.236	-0.261	.008	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051552 vs WDR36 — CCRCC

Explore this scatter interactively →