Flavone metabolic process

Across TCGA patient cohorts, RNA activity of the Flavone metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RIN2, SLC25A29, and SPN_S368, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Flavone metabolic process activity versus RIN2 in CCRCC (Pearson r = -0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RIN2 →	-0.486	-1.750	.002	<.001	3	1
CCRCC	SLC25A29 →	+0.647	+1.645	<.001	<.001	3	1
CCRCC	SPN_S368 →	+1.234	+1.644	.001	<.001	3	1
CCRCC	STRIP2 →	+1.066	+1.660	.001	<.001	3	1
CCRCC	STX11 →	+0.816	+1.670	<.001	<.001	3	1
CCRCC	THRA_S21 →	-1.066	-1.693	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051552 vs RIN2 — CCRCC

Explore this scatter interactively →