Regulation of keratinocyte migration

Across TCGA cell cohorts, RNA activity of the Regulation of keratinocyte migration pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTOR, RPTOR, and ADAM9, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MTOR grouped by Regulation of keratinocyte migration-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MTOR →	-0.503	-1.273	.005	.002	3	10
SKIN	RPTOR →	-0.216	-1.035	.008	.002	3	5
SOFT_TISSUE	ADAM9 →	-0.311	-1.101	.002	.007	2	6
BLOOD_Leukemia	HBEGF →	-0.289	-0.952	.002	<.001	3	5
LUNG_SCLC	ADGRG3 →	+0.270	+1.397	.003	.001	3	4
SKIN	GSTM2 →	+0.202	+1.097	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MTOR by Regulation of keratinocyte migration activity — STOMACH

Explore this box plot interactively →