Regulation of keratinocyte migration

Across TCGA cell cohorts, RNA activity of the Regulation of keratinocyte migration pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MACROD2, NBN, and FBXL13, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MACROD2 grouped by Regulation of keratinocyte migration-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	MACROD2 →	-0.761	-1.241	.001	<.001	3	4
STOMACH	NBN →	+0.600	+0.869	.001	.005	3	4
SKIN	FBXL13 →	-0.827	-1.088	.007	<.001	3	4
SKIN	DGAT2 →	-1.657	-0.987	.005	.002	3	4
SKIN	CHFR →	-0.667	-0.940	.009	<.001	3	4
OVARY	AKT3 →	-1.425	-0.815	.007	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MACROD2 by Regulation of keratinocyte migration activity — CNS

Explore this box plot interactively →