Regulation of keratinocyte migration

Across TCGA cell cohorts, RNA activity of the Regulation of keratinocyte migration pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIM16, CYP3A7, and EFHB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRIM16 grouped by Regulation of keratinocyte migration-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TRIM16 →	+0.182	+1.093	.006	.004	3	3
URINARY_TRACT	CYP3A7 →	-0.176	-1.759	.006	<.001	2	4
LUNG_NSCLC_LUAD	EFHB →	+0.345	+1.186	.003	.003	3	3
STOMACH	ATF1 →	+0.314	+1.985	<.001	<.001	3	3
STOMACH	LGSN →	-0.176	-1.460	.007	.005	2	4
STOMACH	IRX6 →	+0.196	+1.621	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRIM16 by Regulation of keratinocyte migration activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →