Regulation of keratinocyte migration

Across TCGA cell cohorts, RNA activity of the Regulation of keratinocyte migration pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC88A, ING5, and ALS2CL, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of keratinocyte migration activity versus CCDC88A in LARGE_INTESTINE (Pearson r = -0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCDC88A →	-2.189	-1.469	.001	<.001	3	6
LUNG_NSCLC_LUAD	ING5 →	-0.547	-0.841	<.001	<.001	3	6
STOMACH	ALS2CL →	+2.828	+1.779	.002	<.001	3	6
STOMACH	TMEM265 →	+3.956	+1.894	<.001	<.001	3	6
STOMACH	FA2H →	+3.324	+1.589	<.001	<.001	3	6
STOMACH	MAL2 →	+3.964	+1.529	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051547 vs CCDC88A — LARGE_INTESTINE

Explore this scatter interactively →