Keratinocyte migration

Across TCGA cell cohorts, RNA activity of the Keratinocyte migration pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SH3KBP1, SUZ12, and ACTR3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Keratinocyte migration activity versus SH3KBP1 in OESOPHAGUS (Pearson r = -0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SH3KBP1 →	-1.775	-1.800	<.001	<.001	3	3
OESOPHAGUS	SUZ12 →	-0.894	-1.446	.001	.001	3	3
LUNG_NSCLC_LUAD	ACTR3 →	-0.815	-1.341	.002	.004	3	3
LUNG_NSCLC_LUAD	AK6 →	-0.767	-0.934	.007	.008	3	3
STOMACH	KCTD15 →	+3.253	+1.916	.002	<.001	3	3
STOMACH	ZNF618 →	+2.348	+1.848	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051546 vs SH3KBP1 — OESOPHAGUS

Explore this scatter interactively →